The Khellin Quinone. Erratum

The bronchodilator action of khellin.

This paper describes a preliminary investigation into the bronchodilator action of khellin in patients with clinical bronchospasm. Khellin is one of the active principles of the plant Ammi visnaga (Linn.), which grows wild in many eastern Mediterranean countries. Simple decoctions of its seeds have apparently been used by the local native populations for generations as a spasmolytic, in particu...

Erratum

Effect of Khellin on Coronary Artery

The effectiveness of khellin in 9 patients with angina pectoris was evaluated electrocardiographically by means of the exercise tolerance, anoxemia and ergonovine tests. Normalization occurred in the majority of the previously abnormal tests following khellin therapy. A beneficial effect was noted on symptoms accompanied by a reduction in nitroglycerin requirement. Mild toxicity, as a result of...

Khellin in the treatment of angina of effort.

Anrep, Kenawy, and Barsoum (1949) have given a historical account of the pharmacology of khellin, which is the active principle of the plant Ammi visnaga, from its preparation by Mustapha in 1879 and the biological studies of Samaan (1932) to their own extensive investigations, already published in various articles and now summarized and brought up to date in their latest review. They have show...

Computational study of khellin excited states and photobinding to DNA.

A theoretical investigation of the formation and spectroscopic properties of the furan and pyrone monoadducts between the photosensitizer khellin and DNA base thymine is reported. The thermal reaction pathways involve very high barriers, whereas the excited state surfaces display low barriers in regions leading to the ground state TS structures and potential wells at the ground state TS geometr...